Chapter Listing
Introduction
Movement Disorder Characteristics
Most Common Movement disorders
Main Symptoms
Atypical Symptoms
Reduction of Symptoms
Symptom Presentation
Historical Aspects
Burden of Illness
Prevalence in the General Population
Global and Regional Prevalence
REST Population Study
Prevalence of RLS
Risk Factors
Antidepressants
Reduced Quality of Life
Impact on Daytime Functions
Age of Onset
Pathophysiology
RLS Genetics
Genetics
Hereditary RLS
Heritability in RLS
Chromosome Loci
Electrophysiology
Circadian Pattern
Imaging Studies
Functional Connectivity
PET Studies
MRI Iron Imaging
Brain Imaging
Neurochemistry
Dopamine metabolism
Opioid system
Iron system
Glutamate
Morbidity
Mortality
Discomfort and pain
Sleep disturbance
Sleep quality and sleepiness
Psychological effects
Risk of Suicide
Hypertension
Heart Disease
Stroke-Related RLS
Peripheral Hypoxia in RLS
RLM
OSA
Diagnostic Criteria
Common Misdiagnoses
Secondary RLS
Parkinson’s Disease
ADHD and RLS
Rheumatoid Arthritis
Peripheral Neuropathy
Medications and RLS
Pregnancy and RLS
Diabetes and RLS
Multiple Sclerosis
Spinocerebellar Ataxia
Behcet’s Disease
Cystic Fibrosis and RLS
Epilepsy
Iron Deficiency
Renal Disease
Differential Diagnosis
Diagnostic Tools
Questionnaires
Polysomnography
Immobilization Tests
Suggested Immobilization Test
Actigraphy
Management of RLS
Treatment
Dopaminergic Medications
Pramipexole
Pramipexole Studies
Pergolide
Ropinirole
Cabergoline
Cabergoline Studies
Carbidopa/Levodopa
Cabergoline/Levodopa
Rotigotine Transdermal Patch
Lisuride Transdermal Patch
Apomorphine
Opioids and Tramadol
Methadone for RLS
Benzodiazepines
Alpha 2 – Delta Ligands
Gabapentin
Gabapentin Enacarbil
Pregabalin
Pregabalin with Pramipexole
Suvorexant for Sleep, Motor and Sensory Symptoms
Iron Treatment
IV Iron Treatment
Sleep and Iron
Predictors of Placebo Response
Placebo and Nocebo
Pharmacological Responsiveness of PLMS in RLS Patients
Augmentation
Management of Augmentation
Behavioral treatments
Exercise
Acupuncture
Vibrating Pads
Treatment Protocols
Children
Pregnancy
Pregnancy – RLS Prevalence
Pregnancy-Pharmacological Management
RLS in Women During Pregnancy and Lactation
RLS Foundation
