Narcolepsy

NARCOLEPSY

Definition
History
Prevalence
Health Care Utilization
Comorbid Medical Disorders
Comorbid Psychiatric Disorders
Executive Functions
Onset of symptoms
Age of First Consultation
Narcolepsy in children
Symptoms
Secondary Narcolepsy
Excessive sleepiness
Sleep onset REM period
Nocturnal SOREMP
MSLT specificity
Test-Retest Reliability of the MSLT
MSLT and PSG and Hypersomnolence
MSLT criteria
Frequency of sleep episodes
Additional Features
Cataplexy
Muscles affected
Onset of cataplexy
Situations that induce cataplexy
Detection of cataplexy
Duration of cataplexy
Features of cataplexy
Cataplexy electrophysiology
Cataplexy and reflexes
Cataplexy vs no cataplexy
Laughter and Narcolepsy
Nocturnal Compulsive Behaviors
Sleep paralysis
Dreams
Nightmares
Hypnagogic hallucinations
Frequency
Content
Disturbed nocturnal sleep
Nocturnal awakenings
Sleep fragmentation
Sleep apnea
Anesthetics and Surgery
Periodic limb movements
Obesity
Cardiovascular Disorders
Precocious Puberty
REM sleep behavior disorder
Increased muscle activity
Motor Dyscontrol in Narcolepsy
ADCA – DN
Animal narcolepsy
Canine narcolepsy
Rodent narcolepsy
Mechanisms of Cataplexy in Narcolepsy
Motor Tone
Amygdala and Narcolepsy
Hyperperfusion
Brain Correlates of Cataplexy
Neurochemistry
Neuroanatomy
Functional neurophysiology
Cytokines
Genetics
Familial risk of narcolepsy
Monozygotic twin studies
Genome wide association studies
P2RY11
Autoimmunity and narcolepsy
HLA DQB1
HLA system in narcolepsy
T Cell Receptor Gene
Risk Loci Outline of T Cell Autoimmunity
Tribbles Homolog 2
Streptococcal Antibodies
H1N1
Antibodies to Vaccine and Hypocretin
Hypocretin
Hypocretin – Neurochemical
Hypocretin – Pathways
Opioids Increase Number of Hypocretin/Orexin Neurons
SO Increases the Size of Hypocretin/Orexin Neurons
ON-SXB and Disrupted Nighttime Sleep
Epigenetic Silencing of Narcolepsy
Hypocretin, NARP, Dynorphin
Hypocretin – Cell Loss
Hypocretin – Narcolepsy without Cataplexy
Hypocretin – Deficiency
Hypocretin – Genetics
Csf Hypocretin levels?
Hypocretin levels in sleep disorders
Hypocretin – Neurological
Hypocretin – HLA
Hypocretin – Histamine
Histamine Cell Increase
Histamine Hypocretin Interaction Model
Clinical diagnosis
Levels of certainty for diagnosis
Epworth sleepiness scale
Psychiatric features
Quality of life
Psychosocial aspects
Demographics and Health Characteristics
Work Productivity Loss
Economic burden of narcolepsy
Polysomnography
Sleep Stage Transitions
Differential diagnoses
Symptomatic narcolepsy
Posttraumatic narcolepsy
Parasomnias
Treatment
Behavioral treatment
Naps on performance
Effect of meals on napping
Pharmacological treatment
Neurochemical rationales for treatment
Treatment – sleepiness
Alerting agents
Efficacy of stimulants
High-Dose stimulants
Drug Abuse
Side effects of agents
Modafinil site of action
MWT and modafinil
Modafinil in previously treated patents
Split dose effects
Armodafinil
Sodium Oxybate Effects
Wakefulness Promoting Agents
Pharmacotherapy of cataplexy
Treatment – cataplexy
Medication effect on cataplexy
Mode of action
Sodium Oxybate
Gammahydroxybutyrate
Efficacy in Cataplexy
Sodium Oxybate on Sleepiness
Sodium Oxybate – Treatment
Future directions in treatment
Solriamfetol
Histaminergic H3 antagonists
Pitolisant
Hypocretin and analogues
Orexin 2 Receptor Agonist
Agents under development
TAK – 861
Thyrotrophin
Hypocretin cell transplantation
Hypocretin Gene transfer
Immune-based therapies
GABA-B Agonism
Treatment – nocturnal sleep
Treatment – sleep paralysis
Treatment – PLM’s
Treatment – psychosocial
Pregnancy
Contraception
GHB and Breast Milk
Children
Mortality

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