Chapter Index:
Introduction
Narcolepsy
Diagnosis Criteria
Orexin Pathways
Hypocretin
Orexin Neuron Activity
Ligand and Genes
Orexin Receptors
Other Orexin Functions
Specific Clusters
Orexin Receptor Activity
Cardiovascular Physiology
BP Dipping in Narcolepsy
Sleep Fragmentation
Orexins Role in REM Sleep
Orexins Role in Cataplexy
Melanin-Concentrating-Hormone
MCH Neurons
Orexin Neuron Loss
Hypocretin Deficiency in Human Narcolepsy
Pathophysiology of Narcolepsy
REM features in Narcolepsy
Precious Puberty
Hypocretin/Orexin Levels
Narcolepsy without Cataplexy
Narcolepsy Spectrum Disorder
Progressive Narcolepsy
Changing Orexin Levels
Therapeutic Interventions
Orexin Treatment in Narcolepsy
Agonists Under Development
Orexin Replacement
Orexin Gene Therapy
Orexin 2 Receptor Agonist
TAK-925 (iv)
TAK-925
TAK-994
Alkermes 2680 Ox2r Agonist
Centessa ORX750
TAK-861
JZP-441
Role of OX2R agonists in Narcolepsy
Dual OX1R/OX2R Agonists
Orexin agonists are a class of drugs that target and activate the orexin system in the brain, which plays a key role in regulating wakefulness, arousal, and energy balance.